Fragment Based Drug Design, Volume 493: Tools, Practical Approaches, and Examples (Methods in Enzymology)

There are a number of very good reports on fragment-based drug discovery (FBDD), yet there are thus far no hand-holding courses or protocols with which you may embark in this orthogonal method of supplement conventional excessive throughput screening methodologies. This Methods in Enzymology quantity bargains the instruments, functional techniques, and hit-to-lead examples on find out how to behavior FBDD monitors. The chapters during this quantity hide tools that experience confirmed to achieve success in producing leads from fragments, together with chapters on the best way to practice computational concepts, nuclear magnetic resonance, floor plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. additionally elaborated via skilled researchers in FBDD are pattern arrangements of fragments, proteins, and GPCR in addition to examples of ways to generate leads from hits.

Offers the instruments, functional techniques, and hit-to-lead examples on the best way to behavior FBDD monitors The chapters during this quantity disguise tools that experience confirmed to achieve success in producing leads from fragments, together with chapters on tips to follow computational concepts, nuclear magnetic resonance, floor plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD

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