The Logic of Chance: The Nature and Origin of Biological Evolution (paperback)

By Eugene V. Koonin

The good judgment of Chance bargains a reappraisal and a brand new synthesis of theories, ideas, and hypotheses at the key elements of the evolution of lifestyles on the earth in gentle of comparative genomics and platforms biology. the writer provides many particular examples from platforms and comparative genomic research to start to construct a brand new, even more special, complicated, and sensible photograph of evolution. The publication examines a huge diversity of issues in evolutionary biology together with  the inadequacy of traditional choice and variation because the basically or perhaps the most mode of evolution; the main position of horizontal gene move in evolution and the resultant overhaul of the Tree of existence concept;  the critical, underappreciated evolutionary value of viruses; the foundation of eukaryotes due to endosymbiosis; the concomitant beginning of cells and viruses at the primordial earth; common dependences among genomic and molecular-phenomic variables; and the evolving panorama of constraints that form the evolution of genomes and molecular phenomes.


"Koonin's account of viral and pre-eukaryotic evolution is absolutely up to date. His "mega perspectives" of evolution (given what used to be acknowledged above) and his cosmological musings, nonetheless, are fascinating reading." Summing Up: Recommended

Reprinted with permission from selection, copyright via the yankee Library organization.


Show description

Preview of The Logic of Chance: The Nature and Origin of Biological Evolution (paperback) PDF

Best Biology books

10% Human: How Your Body's Microbes Hold the Key to Health and Happiness

You're simply 10% human. for each one of many cells that make up the vessel that you simply name your physique, there are 9 impostor cells hitching a trip. you're not simply flesh and blood, muscle and bone, mind and epidermis, but in addition micro organism and fungi. Over your lifetime, you'll hold the identical weight of 5 African elephants in microbes.

Who's in Charge?: Free Will and the Science of the Brain

“Big questions are Gazzaniga’s inventory in exchange. ”—New York Times“Gazzaniga is without doubt one of the so much great experimental neuroscientists on the planet. ”—Tom Wolfe“Gazzaniga stands as an incredible between neuroscientists, for either the standard of his study and his skill to speak it to a normal public with infectious enthusiasm.

Fragment Based Drug Design, Volume 493: Tools, Practical Approaches, and Examples (Methods in Enzymology)

There are many first-class reports on fragment-based drug discovery (FBDD), yet there are to this point no hand-holding courses or protocols with which you could embark in this orthogonal method of supplement conventional excessive throughput screening methodologies. This tools in Enzymology quantity bargains the instruments, useful methods, and hit-to-lead examples on tips on how to behavior FBDD displays.

The Invisible History of the Human Race: How DNA and History Shape Our Identities and Our Futures

• A manhattan Times Notable e-book •“The richest, most up to date, most enjoyable booklet on genetics in a while. ” —The big apple occasions publication evaluation we're doomed to copy heritage if we fail to profit from it, yet how are we suffering from the forces which are invisible to us? within the Invisible historical past of the Human Race Christine Kenneally attracts on state of the art examine to bare how either old artifacts and DNA let us know the place we come from and the place we should be going.

Additional info for The Logic of Chance: The Nature and Origin of Biological Evolution (paperback)

Show sample text content

As we will see within the subsequent sections, this distinction is important as a determinant of the process evolution as the s values for the valuable 舠embellishments舡 of complicated genomes, comparable to introns, lie inside of that diversity. hence, they're more often than not eradicated via purifying choice in organisms with huge Ne yet now not in organisms with small Ne. Evolutionary conservation of any genomic point doesn't immediately suggest that the conserved point is limited by way of purifying choice because of its useful significance; a little bit sarcastically, it will possibly mirror susceptible purifying choice that's inadequate to put off non-adaptive ancestral beneficial properties (Koonin and Wolf, 2010b). definitely, Ne isn't really consistent during the evolutionary historical past of a lineage. to the contrary, huge fluctuations virtually inevitably ensue, resulting in inhabitants bottlenecks (intervals of low Ne) in which evolution relies virtually totally on float in order that a number of just a little or even reasonably deleterious genomic adjustments could be fastened, delivering uncooked fabric for next evolution. it is very important detect that even populations with huge Ne can repair just a little deleterious mutations through draft/hitchhiking (see bankruptcy 2) and, furthermore, hold a wide cache of impartial and weakly deleterious mutations that by no means visit fixation, yet could persist within the inhabitants as polymorphisms for a very long time. a few of these chronic nonfixed mutations may match to fixation swiftly whilst selective strain alterations and a mutation turns into priceless, or while a brand new mutation creates a useful mixture with one of many continual polymorphisms. field 8-1: inhabitants features and contours of genome association in varied mobile lifestyles types the information on Ne and Neu comes from Lynch, 2006; the knowledge on intron density comes from Csuros, et al. , 2011; for the intron density in prokaryotes, 舠not appropriate舡 is indicated, given the absence of the spliceosome. this easy (and awarded the following in a intentionally oversimplified shape) idea steeped in inhabitants genetics presents the null speculation for genome evolution (Koonin, 2004). within the subsequent sections, we think about this conception in a few extra element and, most significantly, see the way it holds opposed to comparative genomic info. Gene structure in eukaryotes: A exhibit for the non-adaptive concept of genome evolution Evolution of the exon-intron gene constitution in eukaryotes (see additionally bankruptcy 7) is a superb for instance for the non-adaptive inhabitants genetic paradigm that enables one to higher take hold of the speculation and its predictions. sooner than we talk about the specifics of gene structure evolution from this angle, it is crucial to appreciate the relationship among the choice coefficient s and the weight of deleterious mutations imposed via an additional genomic aspect (Koonin, 2009b; Lynch, 2007b, 2007c). each one point extra to a genome magnifies its vulnerability to mutational inactivation and so 舠encourages舡 the removal of that point from the inhabitants. whilst an embellishment calls for the conservation of n nucleotides for the respective gene to take care of its performance, this requirement evidently creates the room for n deleterious mutations to happen, so the mutational drawback is s = nu.

Download PDF sample

Rated 4.50 of 5 – based on 41 votes